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in reducing the permeability of capillaries and the number of mast cells that produce hyaluronic acid. The immunosuppressive effect is due to inhibition of the release of cytokines (interleukin – 1,2, gamma interferon) from lymphocytes and macrophages, inhibition of proliferation of lymphoid tissue and cellular immunity, and a violation of the kinetics of T-lymphocytes. Buy Cortexonavet online, cortexona retard , cortexonavet 50 ml, cortexonavet dosage,cortexonavet para que sirve
cortexona retard is prescribed to cattle, sports and work horses, pigs, dogs and cats as an anti-inflammatory, anti-allergic, anti-edematous and gluconeogenetic drug in the treatment of post-traumatic edema, cortexona arthritis, tenosynovitis, as well as acute mastitis and cattle syndrome, cattle syndrome, mastitis-agalactia of sows, allergic dermatitis and eczema in dogs and cats. cortexona Trade name of the medicinal product for cortexona:
Cortexona retard.
International nonproprietary name cortexona:
Dexamethasone.Dosage form:
Suspension for injection.Composition for Cortexon:
Cortexon retard in 1 ml contains:
As an active ingredient – dexamethasone (isonicotinate) – 1.25 mg;
Excipients:
– sodium chloride;
– polysorbate 80;
– benzyl alcohol
– water for injection.In appearance, the drug is an aqueous suspension of white color. With prolonged storage, it may delaminate, which disappears with shaking.Pharmacological properties for cortexona:Buy Cortexonavet online
Pharmacotherapeutic group: hormonal drug. Dexamethasone, which is part of the drug, is a glucocorticosteroid, methylated derivative of fluoroprednisolone. It has a pronounced and prolonged anti-inflammatory, anti-allergic, desensitizing effect, and has immunosuppressive activity.
The mechanism of action of the hormone is to block the release of inflammatory mediators by eosinophils, including prostaglandins
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which potentiate the inflammatory process, in stimulating the biosynthesis of lipocartins with decongestant activity;
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The main effect of dexamethasone on metabolism is associated with protein catabolism, increased gluconeogenesis in the liver, and decreased glucose utilization by peripheral tissues.
After intramuscular administration, the maximum plasma concentration of dexamethasone is detected after 60 minutes.cortexona The therapeutic concentration in the blood serum lasts 30-96 hours, depending on the type of animal. cortexonavet para que sirve, cortexonavet 50 ml
The bioavailability of dexamethasone with intramuscular injection of the drug is 100%. Biotransformation of dexamethasone occurs in the liver and partially in the fibroblasts involved in the metabolism. As a result, 17-hydroxycorticoids are formed that do not have biological activity, and 17-ketosteroids with androgenic effect are formed as well.
Metabolites bind to glucuronic acid and sulfates in the liver and kidney x, where they turn into water-soluble sulfuric esters and ricoronids, which are rapidly excreted in urine (75%) and bile (25%). cortexona retard in terms of exposure to the body belongs to moderately hazardous substances (hazard class 3 according to GOST
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cortexona retard is prescribed to cattle, sports and workhorses, pigs, dogs and cats as an anti-inflammatory, anti-allergic, anti-edematous and lucon-essential drug in the treatment of post-traumatic edema, arthritis, tenosynovitis, and acute thymus and cattle mastitis, sows metritis-mastitis-aalactia syndrome, allergic dermatitis and eczema in dogs and cats. The drug is administered to animals once intramuscularly in the following doses:
– to cattle, horses, pigs – 1 ml. by 62.5 kg. animal mass;
– calves, foals, piglets – 1ml. 40 kg. animal mass;
– dogs – 0.5 ml. 8 kg. animal mass;
– for cats – 0.25 ml. 2 kg. mass of the animal. If necessary, the injection is repeated in the same dose after 10-14 days. cortexonavet para que sirve
Before use, the drug bottle should be thoroughly shaken.
There were no specific features of the action during the first use of the drug or during its withdrawal. cortexona retard should not be used in pregnant animals in the last third of pregnancy. The use of corticosteroids in lactating a can cause a short-term decrease in milk productivity.
The use of the drug to stimulate labor can cause a decrease in the viability of the fetus, and also increase the frequency of retel of the placenta. cortexonavet dosage
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A drug is usually used once. Contraindications for cortexona:
A contraindication to the use of the drug is the individual hypersensitivity of the animal to one of the components of the drug (including a history). Buy Cortexonavet online
Not recommended for use in animals with diabetes; with hepatic, renal, or heart failure; peptic ulcer of the stomach and duodenum; with bone fractures and osteoporosis; with degenerative diseases of the eyes and / or corneal ulcer; with hyperadrenocorticalism. cortexona retard
Animals suffering from bacterial, fungal and / or viral diseases, cortexona retard should be used using etiotropic and pathogene therapy. If it is necessary to use the drug in such cases, treatment of animals should be carried out under the strict supervision o veterinarian. cortexonavet dosage
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Cortexon retard is forbidden to use for horses whose meat and milk are used as human food. Side effects and overdose cortexor In case of overdose, horses may experience drowsiness.Side effects and complications when using cortexona retard in accordar with this instruction, as a rule, are not observed.
With prolonged use, the manifestation of Cushing’s syndrome is possible, which causes redistribution of fat in the body, muscle weakness, weight loss and osteoporosis.
Polyuria, polydipsia and polyphagy are possible. In the event of allergic reactions, the use of the drug is stopped and, if necessary desensitizing therapy is prescribed.cortexona retard is not recommended for use with other glucocorticosteroids, anti-diabetes Buy Cortexonavet online
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