Modulis 100 mg/mL Oral Solution 50 mL – Targeted Immunomodulation for Allergic Dermatitis in Dogs

Modulis 100 mg/mL Oral Solution 50 mL is a veterinary-prescribed immunomodulatory treatment designed to manage chronic allergic and atopic dermatitis in dogs. It contains cyclosporine, a potent calcineurin inhibitor that selectively suppresses certain immune responses, thereby reducing inflammation, itching, and other skin-related symptoms associated with allergic reactions. modulis 100 mg 50 ml

This formulation is presented as a clear, pale-yellow oral solution in a 50 mL bottle and includes a dosing syringe for precise administration.

Indications & Uses

Modulis® is indicated for:

Atopic Dermatitis – Chronic skin condition caused by environmental allergens.

Allergic Dermatitis – Includes flea allergy dermatitis, food allergy-related skin inflammation, and contact dermatitis.

Immune-mediated Skin Disorders – Reducing immune system overactivity that leads to pruritus, erythema, excoriations, and alopecia.

It is particularly effective when antihistamines or corticosteroids are ineffective or contraindicated.

Mechanism of Action

Cyclosporine inhibits the activation of T-lymphocytes by blocking calcineurin. Modulis 100 mg/mL Oral Solution 50 mL

This reduces the release of inflammatory cytokines such as interleukin-2.

The result is decreased skin inflammation, less redness, and significant reduction in itching.

Key Benefits

Fast Symptom Relief – Noticeable improvement in itching and redness within 2–4 weeks.

Steroid-Sparing Alternative – Avoids the long-term side effects of corticosteroid use.

Precise Dosing – Oral solution allows accurate, weight-based dosing for all dog sizes.

Well-Tolerated for Long-Term Use – Suitable for chronic conditions with proper monitoring.

Dosage & Administration

Route: modulis 100 mg 50 ml precio Oral

Initial Dose: 5 mg/kg body weight once daily.

Administer directly into the dog’s mouth using the supplied syringe or mix with a small amount of food.

Give on an empty stomach (at least 2 hours before or after feeding) for best absorption.

Once symptoms are controlled, the dose may be reduced to every other day or the lowest effective frequency.

Important: Always follow the dosing schedule prescribed by the veterinarian.

Safety & Precautions

Contraindications:

Dogs with known hypersensitivity to cyclosporine.

Dogs with a history of malignant disorders (neoplasia).

Use with Caution:

In dogs with kidney or liver disease.

In dogs with diabetes mellitus (may cause increased blood glucose).

Modulis 100 mg/mL Oral Solution 50 mL Adverse Reactions:

Gastrointestinal upset (vomiting, diarrhea, reduced appetite).

Gingival hyperplasia (overgrowth of gums).

Rarely: lethargy, muscle weakness, urinary tract infections.

Drug Interactions: Avoid concurrent use with drugs affecting cytochrome P-450 enzymes (e.g., ketoconazole, erythromycin) unless advised by a vet.

Storage Instructions

Store at 15–25 °C (59–77 °F).

Protect from light and moisture.

Once opened, use within 16 weeks.

Advantages Over Other Treatments

Long-term use without typical steroid side effects.

More targeted immune suppression compared to broad-spectrum drugs.

Flexible dosing adjustment once the condition stabilizes. Modulis 100 mg/mL Oral Solution 50 mL