where to buy marquis paste for horses

Marquis® is the first FDA-approved treatment for Equine Protozoal Myeloencephalitis (EPM) — a neurologic disease in horses caused by the protozoan Sarcocystis neurona. It helps stop the spread of the protozoa in the central nervous system and allows the horse’s immune system to regain control. where to buy marquis paste for horses

Mechanism of Action

Ponazuril is a triazine-class antiprotozoal that:

Inhibits protozoal mitochondrial function

Interferes with energy metabolism

Halts the replication of Sarcocystis neurona

Indications (Uses)

Marquis® is indicated for:

Treatment of Equine Protozoal Myeloencephalitis (EPM) caused by Sarcocystis neurona

Not approved for prevention. Treatment must start early for best results.

Target Species

Horses only

marquis paste Dosage and Administration

Standard Dose:

5 mg/kg (2.27 mg/lb) body weight

Administer once daily for 28 days

Dosing Syringe Details:

Each 127 g tube delivers 28 doses for a 1,200 lb horse

Plunger dial allows easy weight-based adjustment

How to Administer:

Insert tube into the horse’s mouth

Place on the back of the tongue

Depress plunger fully

Do not feed immediately afterward where to buy marquis paste for horses

Onset of Action

Clinical improvement may be seen within 7–14 days

Neurological deficits may take weeks to months to improve fully

Horses must complete the 28-day course

Warnings and Contraindications

Do NOT use in foals under 4 months unless advised by a vetwhere to buy marquis paste for horses

Not studied in pregnant or breeding horses

CNS symptoms may temporarily worsen as parasites die off

Must be used with a confirmed EPM diagnosis – clinical and/or CSF antibody tests

Side Effects

Common:

Decreased appetite

Mild colic signs

Lethargy

Rare:

Diarrhea

Neurologic worsening early in treatment

Note:

Side effects are typically transient

Monitor for worsening neurologic signs during the first week

Storage Conditions

Store at room temperature (15°C–30°C / 59°F–86°F)

Keep cap tightly closed after each use

Do not refrigerate or freeze

Pharmacokinetics

Oral bioavailability: ~30–40%

Steady-state reached in 4–5 days

Half-life: 4–5 days, allowing once-daily dosing

Crosses the blood-brain barrier to reach CSF where to buy marquis paste for horses

Product Summary Table

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Veterinary Insight

Early treatment = best prognosis

A neurologic exam and serologic testing (Western blot or ELISA) should be done before treatment

In some cases, a second 28-day course may be required

Combining Marquis® with anti-inflammatory meds (e.g., flunixin) during first few days can help manage immune reactions where to buy marquis paste for horses

Horses may require neurological rehab or physical therapy

Alternatives to Marquis® Paste