marbocyl 10 100ml
marbocyl 10 100ml is a broad-spectrum fluoroquinolone antibiotic used to treat bacterial infections in animals, especially cattle, pigs, and dogs. It is primarily used to combat infections caused by Gram-negative and some Gram-positive bacteria, including those resistant to other antibiotics.
Mechanism of Action
Marbofloxacin:
Belongs to the fluoroquinolone class
Inhibits DNA gyrase and topoisomerase IV – essential enzymes for bacterial DNA replication
Results in bactericidal action (kills bacteria rather than just inhibiting growth)
Indications (Approved Uses)
Used in veterinary medicine to treat infections such as:
Cattle (Bovine):
Respiratory infections (bovine respiratory disease – BRD) caused by Pasteurella, Mannheimia, and Histophilus
Acute mastitis caused by E. coli
Swine (Porcine):
Respiratory tract infections caused by Actinobacillus pleuropneumoniae, Pasteurella multocida
Metritis-mastitis-agalactia (MMA) syndrome
Dogs and Cats:
Skin infections (pyoderma)
Urinary tract infections
Respiratory infections
Otitis externa/media (off-label)
Target Species
Cattle
Swine
Dogs (Marbocyl P tablets preferred)
Cats (off-label or with Marbocyl oral)
marbocyl 10 100ml Dosage and Administration
| Species | Route | Dosage | Duration |
|---|---|---|---|
| Cattle | IM, SC, IV | 2 mg/kg once daily | 3–5 days |
| Swine | IM | 2 mg/kg once daily | 3–5 days |
| Dogs/Cats | SC or IM | 2–4 mg/kg once daily | 3–10 days |
low IV use in cattle allowed under supervision
Volume limits may apply per injection site
Pharmacokinetics marbocyl 10 100ml
Absorption: Rapid after injection
Bioavailability: ~90%
Half-life: ~5–9 hours depending on species
Distribution: Well-distributed in tissues, especially lungs and urinary tract
Contraindications
Do NOT use in animals with hypersensitivity to fluoroquinolones
Not for young growing animals due to cartilage damage risk (e.g., foals, puppies <12 months)
Do not use in pregnant or lactating animals unless deemed necessary
Avoid concurrent NSAIDs (increased risk of seizures)
marbocyl 10 100ml Side Effects and Precautions
Common:
Local swelling or discomfort at injection site
Rare:
Nervous signs: ataxia, tremors
Allergic reactions
GI upset (especially in small animals)
Precautions:
Use with caution in animals with CNS disorders
Do not exceed dose
Ensure sterile technique to avoid abscess formation
Withdrawal Times (Withholding Periods)
| Species | Route | Meat | Milk |
|---|---|---|---|
| Cattle | IM or SC | 6 days | 36 hours |
| Swine | IM | 4 days | Not applicable |
Always verify with local regulatory authorities or product label in your region.
Storage Conditions
Store below 25°C (77°F)
Protect from light
Do not freeze
Use within 28 days after first opening (multidose vial) marbocyl 10 100ml
Product Summary Table
| Attribute | Details |
|---|---|
| Brand Name | Marbocyl 10% |
| Generic | Marbofloxacin |
| Concentration | 100 mg/mL |
| Form | Injectable solution |
| Volume | 100 mL vial |
| Species | Cattle, swine, dogs (off-label for others) |
| Antibiotic Class | Fluoroquinolone |
| Action | Bactericidal |
| Use | Respiratory, urinary, skin, and systemic infections |
| Withholding Time | 4–6 days meat, 36 hrs milk |
| Prescription | ✅ Veterinary Rx required |
Veterinary Insight
Highly effective in respiratory and urinary tract infections
A preferred antibiotic in difficult-to-treat Gram-negative infections
Best reserved for serious infections due to resistance concerns
Ensure appropriate diagnosis and culture/sensitivity when possible marbocyl 10 100ml
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