Nimesulide and Paracetamol Injection Veterinary

Nimesulide and Paracetamol Injection Veterinary is a combination veterinary medication that combines two complementary therapeutic agents: nimesulide (a COX-2 selective NSAID) and paracetamol (acetaminophen, an analgesic and antipyretic). Nimesulide Paracetamol is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

Active Ingredients and Mechanism

Nimesulide Component:

Veterinary Nimesulide Paracetamol Injection is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class which acts by inhibition of prostaglandin synthesis, thereby exerting anti-inflammatory, anti-endotoxic, ant exudative, analgesic and antipyretic properties.

Dual-Action Mechanism:

Nimesulide: COX-2 selective inhibition providing anti-inflammatory, analgesic, and antipyretic effects

Paracetamol: Central analgesic and antipyretic action through different pathways

Synergistic Effect: Combined action provides enhanced pain relief and fever reduction Nimesulide and Paracetamol Injection Veterinary

Additional Properties:

In addition, nimesulide has a range of other anti-inflammatory effects, including inhibition of the neutrophil oxidative response and inhibition of platelet activating factor.

Clinical Indications

Cattle Applications:

CATTLE – For use in acute respiratory infection and diarrhoea in combination with appropriate antibiotic therapy to reduce clinical symptoms in calves and young cattle. For use in acute mastitis, in combination with antibiotic therapy, as appropriate, to reduce clinical symptoms in lactating cows.

Specific Cattle Uses:

Respiratory Infections: Adjunct therapy with antibiotics for respiratory disease

Diarrhea: Supportive treatment in combination with antimicrobials

Mastitis: Adjunct to antibiotic therapy for inflammatory symptoms

Fever Reduction: Control of pyrexia associated with infectious conditions

Swine Applications:

PIGS – For use in acute non-infectious locomotor disorders to reduce the symptoms of lameness and inflammation. For use in puerperal septicaemia and toxaemia (mastitis-metritis-agalactia syndrome) with appropriate antibiotic therapy to reduce clinical signs of inflammation. Nimesulide and Paracetamol Injection Veterinary

Specific Swine Uses:

Locomotor Disorders: Treatment of lameness and associated inflammation

MMA Syndrome: Mastitis-metritis-agalactia complex management

Puerperal Conditions: Post-farrowing complications

Inflammatory Conditions: General anti-inflammatory support

General Therapeutic Applications:

Adjunct antibiotics in severe infections to reduce high fever.

Pharmacological Properties

Nimesulide Characteristics:

COX-2 Selectivity: Preferential inhibition of COX-2 over COX-1

Anti-inflammatory: Reduces inflammatory mediator production

Analgesic: Pain relief through prostaglandin inhibition

Antipyretic: Fever reduction via hypothalamic action

Anti-endotoxic: Counters effects of bacterial endotoxins

Paracetamol Characteristics:

Central Action: Primary analgesic and antipyretic effects in the CNS

Complementary Mechanism: Different pathway from NSAIDs

Synergistic Effect: Enhanced overall therapeutic benefit when combined. Nimesulide and Paracetamol Injection Veterinary

Research and Clinical Studies

Canine Studies:

The present experiment was designed to determine a dosage regimen (dose, interval of administration) in the dog for nimesulide, a nonsteroidal anti-inflammatory drug with in vitro selectivity for the inhibition of cyclo-oxygenase 2 (Cox-2), using a pharmacokinetic/pharmacodynamic (PK/PD) approach.

It is commonly used to reduce the pain and inflammation associated with osteoarthritis in dogs.

Dosage and Administration

General Principles:

Injectable formulation for immediate therapeutic effect

Dosage varies by species, body weight, and clinical condition

Professional veterinary administration required

Often used as adjunct therapy with appropriate antibiotics

Administration Routes:

Intramuscular: Primary route for most applications

Intravenous: May be used in specific clinical situations

Professional Oversight: Veterinary supervision required

Combination Therapy Considerations

Antibiotic Combinations:

The product is frequently used in combination with antimicrobial therapy for:

Enhanced clinical response in infectious conditions

Symptomatic relief while antimicrobials address underlying infection

Improved animal comfort and welfare during treatment

Reduced inflammatory complications

Clinical Benefits of Combination:

Comprehensive Treatment: Addresses both infection and inflammation

Improved Outcomes: Better clinical response than single-agent therapy

Animal Welfare: Reduces pain and discomfort during illness

Faster Recovery: May accelerate return to normal function. Nimesulide and Paracetamol Injection Veterinary

Safety Considerations

Professional Use Requirements:

Veterinary prescription required Nimesulide and Paracetamol Injection Veterinary

Professional administration recommended

Proper dosage calculation essential

Monitoring for adverse effects necessary

Contraindications and Precautions:

Avoid in animals with known NSAID sensitivity

Caution in animals with renal or hepatic dysfunction

Monitor for gastrointestinal effects

Consider drug interactions with other medications

Species-Specific Applications

Large Animals (Cattle):

Primary focus on respiratory and mammary gland infections

Supportive therapy in digestive disorders

Post-calving complications management

Swine:

Locomotor disorder management

Reproductive disorder support

Post-farrowing care

Nimesulide and Paracetamol Injection Veterinary  Small Animals:

Research indicates potential applications in dogs and cats, though specific veterinary formulations may vary by region and regulatory approval.

Regulatory Status

The combination product is available through veterinary channels in various international markets, with specific formulations and approved indications varying by country and regulatory authority. Professional veterinary oversight is required for appropriate use. Nimesulide and Paracetamol Injection Veterinary

Clinical Monitoring

Response Assessment:

Monitor for fever reduction

Assess improvement in clinical signs

Evaluate pain and discomfort levels

Watch for potential adverse effects

Treatment Duration:

Typically used for acute conditions

Duration based on clinical response

Professional assessment guides treatment length

May require repeat dosing based on severity

This combination injection provides veterinarians with a valuable tool for managing pain, fever, and inflammation in various species, particularly when used as part of comprehensive treatment protocols that may include antimicrobial therapy for optimal clinical outcomes. Nimesulide and Paracetamol Injection Veterinary