Estrombol

Estrombol is a veterinary injectable medication primarily used to regulate reproductive functions in animals, especially in cattle and horses. The main active ingredient in Estrombol is estradiol benzoate, which is a synthetic form of the hormone estrogen. Estradiol plays a key role in regulating the estrous cycle and is commonly used for reproductive management in livestock. estrombol preço​

Uses of Estrombol:
Synchronization of Estrus (Heat):

Estrombol is commonly used to synchronize the estrous cycle in cattle, particularly in dairy and beef cattle. By administering estradiol benzoate, the timing of estrus can be controlled, allowing for artificial insemination or natural mating to occur at an optimal time.
Induction of Estrus:

It can be used to induce estrus in animals that are not cycling normally, such as in cases of anestrus (absence of estrous cycles) in cows and mares.

Support for Reproductive Protocols:

Estrombol is often included in fixed-time artificial insemination (FTAI) protocols, along with other hormones like progesterone, to better manage breeding schedules.
Treatment of Reproductive Disorders:

It may be used in cases of ovarian dysfunction or hormonal imbalances that affect fertility. In some cases, it can also be used to treat retained placentas in postpartum cows.
Stimulation of Uterine Contractions:

In some animals, Estrombol can be used to stimulate uterine contractions after giving birth to aid in the expulsion of any remaining placental tissues. estrombol preço​

Dosage and Administration:

The dosage of Estrombol varies depending on the animal species, weight, and purpose of treatment. Only a veterinarian should determine the proper dose. Below is a general guideline:

Cattle: The typical dose is between 2-5 mg of estradiol benzoate via intramuscular injection, though this can vary depending on the treatment protocol.
Horses: Estradiol is also used in mares for reproductive management, and the dosage will depend on the mare’s reproductive status and the veterinarian’s plan.
Side Effects and Precautions:
Like any hormonal treatment, Estrombol may have side effects, which include:

The dosage of Estrombol (estradiol benzoate) can vary depending on the species, purpose of treatment, and the veterinarian’s specific protocol. Below are general dosage guidelines, but it’s crucial to administer the drug under veterinary supervision to avoid complications.

General Dosage Guidelines:

Cattle (Estrus Synchronization and Reproductive Management):

Typical dose: 2–5 mg of estradiol benzoate administered via intramuscular injection (IM).
Estradiol is often used as part of estrus synchronization protocols, combined with other hormones such as progesterone and gonadotropin-releasing hormone (GnRH).
Horses (Reproductive Management):

Typical dose: 5–10 mg administered via intramuscular injection (IM).
It is used to induce estrus in mares or synchronize their estrous cycles in some breeding programs.
Small Ruminants (Sheep and Goats):

For estrus synchronization, smaller doses of 0.5–2 mg via intramuscular injection (IM) may be used, depending on the veterinarian’s protocol.
Timing:
The timing of the injection is critical, particularly for estrus synchronization protocols. It is often administered in conjunction with other hormones like progesterone (CIDR devices) and prostaglandins (such as PGF2α).
Consult Your Veterinarian:
Always consult a veterinarian for specific dosing instructions, especially in situations like:

Estrus synchronization
Reproductive disorders
Specific species differences (e.g., cattle vs. horses)
Improper dosing or incorrect timing can lead to complications such as hormonal imbalances or poor reproductive outcomes, so professional guidance is essential.

estrombol preço​

Injection site reactions: Swelling or inflammation may occur at the injection site.
Hormonal Imbalance: Overuse or incorrect administration can lead to disruption of the animal’s natural hormone levels, potentially causing reproductive issues or failure to conceive.
Uterine Problems: In some cases, prolonged use can lead to pyometra (uterine infection) or other uterine disorders.
Suppression of Natural Estrus: Incorrect timing of administration can suppress normal estrous cycles.
Contraindications:
Pregnant animals: Estrombol should not be used in pregnant animals as it could lead to abortion or interfere with the normal progression of pregnancy.
Animals with estrogen-sensitive tumors: Estrogens can stimulate the growth of certain tumors, so Estrombol is not recommended in animals with a history of such tumors.
Veterinary Supervision:
Due to the hormonal effects and potential side effects, it is important to use Estrombol only under the supervision of a licensed veterinarian. The veterinarian will determine the appropriate timing and dosage to ensure the best reproductive outcomes and minimize risks.
Legal Status:
In many regions, the use of estrogens in food-producing animals is regulated due to concerns over hormone residues in meat and dairy products. Be sure to follow local regulations regarding the use of such medications in livestock.

Storage:

Estrombol should be stored in a cool, dry place, away from direct sunlight. It is important to keep the product out of the reach of children and animals not intended for treatment. estrombol preço​
In summary, Estrombol (Estradiol Benzoate) is used to regulate estrous cycles, induce estrus, and support reproductive management in livestock. Proper dosage and administration are crucial, and it should only be used under veterinary guidance to avoid potential side effects and ensure successful treatment outcomes.