Flumetasone

Drug Class: Corticosteroid (Glucocorticoid).
Potency: Flumetasone is about 700 times more potent than cortisol, making it one of the most powerful corticosteroids available.
Formulations: Often available as an injectable solution, topical cream, or in combination with antibiotics for ear and skin preparations.
Mechanism of Action

Flumetasone works by:

Suppressing the production of pro-inflammatory cytokines and mediators.
Inhibiting immune cell migration to inflamed tissues.
Stabilizing lysosomal membranes, reducing tissue damage.
Suppressing immune responses in allergic or autoimmune conditions.
Indications in Veterinary Medicine
Small Animals (Dogs and Cats):
Skin Conditions:

Atopic dermatitis.
Flea allergy dermatitis.
Other inflammatory dermatoses.
Ear Conditions:

Otitis externa (often combined with antibiotics or antifungals).
Autoimmune Disorders:

Pemphigus complex or lupus erythematosus.
Emergency Treatment:

Acute allergic reactions (e.g., anaphylaxis).

Horses:
Musculoskeletal Disorders:

Joint inflammation and tendonitis (often used intra-articularly).
Allergic Conditions:

Respiratory allergies or hives (urticaria).
Livestock (Cattle, Sheep, Goats):
Allergic Reactions:

Treats severe allergic responses (e.g., to insect bites).
Parturition:

Occasionally used to induce labor (though this requires careful veterinary guidance).
Dosage
The exact dosage of Flumetasone varies based on the species, condition, and severity of symptoms. Always follow the veterinarian’s prescription. Below are general guidelines:

Dogs and Cats:

Anti-inflammatory: 0.02–0.04 mg/kg by intramuscular (IM) or intravenous (IV) injection.
Emergency use: Higher doses may be administered for acute allergic reactions.
Horses:

Intra-articular: 6–12 mg, depending on the size of the joint.
Systemic: 0.03–0.1 mg/kg IV or IM as prescribed. flumetasona veterinaria
Cattle:
Anti-inflammatory: 0.02–0.04 mg/kg IV or IM.
Benefits
Fast-Acting: Rapid relief of inflammation and allergic symptoms.
Potent: Effective in severe or refractory cases.
Versatile: Can be used for a wide range of conditions across species.
Side Effects
While Flumetasone is highly effective, its potency increases the risk of side effects, especially with prolonged use.

Short-Term Side Effects:

Increased thirst and urination (polydipsia and polyuria).
Increased appetite.
Temporary weakness or lethargy.
Long-Term Risks:
Adrenal Suppression: Long-term use suppresses natural corticosteroid production, causing adrenal insufficiency if stopped abruptly.
Metabolic Issues: May cause hyperglycemia or diabetes in predisposed animals.
Immunosuppression: Increased susceptibility to infections.
Delayed Wound Healing: Due to impaired immune response.
Laminitis: A serious concern in horses.
Contraindications
Active Infections: Unless paired with appropriate antimicrobial therapy.
Pregnancy: May affect fetal development or induce labor. flumetasona veterinaria
Systemic Fungal Infections: Flumetasone suppresses immune responses, worsening these infections.
Pre-existing Conditions: Use cautiously in animals with diabetes, Cushing’s disease, or gastrointestinal ulcers.
Withdrawal Periods
For food-producing animals, adhere to withdrawal times to avoid drug residues in meat or milk:

Meat: Typically 7–14 days (consult the product label or regulatory guidelines).
Milk: Usually 3–5 days.

Storage

Store at controlled room temperature, protected from light and moisture.
Keep out of reach of children and unauthorized personnel.
Precautions
Always use under veterinary guidance, especially in high-performance or food-producing animals.
Avoid long-term use unless absolutely necessary.
Taper dosage gradually when discontinuing after prolonged use to avoid adrenal insufficiency.