Hemoflor Plus

Hemoflor Plus is an antimicrobial veterinary product primarily used for treating bacterial infections in animals. It combines Florfenicol, a broad-spectrum antibiotic, with other supportive agents to provide effective treatment for respiratory and systemic infections in livestock, including cattle, pigs, and sometimes horses. hemoflor plus para gallos​

Composition of Hemoflor Plus
The active ingredient in Hemoflor Plus is Florfenicol, a synthetic broad-spectrum antibiotic. It belongs to the amphenicol class and is specifically designed for veterinary use, exhibiting effectiveness against a wide range of Gram-positive and Gram-negative bacteria.

Florfenicol:

A potent, broad-spectrum antibiotic effective against pathogens such as Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and other bacterial strains.
Works by inhibiting bacterial protein synthesis, leading to the death of the bacteria.
Additional Components (if present):
Stabilizers or excipients to enhance absorption and efficacy.
Mechanism of Action
Florfenicol in Hemoflor Plus acts by inhibiting bacterial ribosomes (70S ribosomal subunit), blocking protein synthesis. This action is bacteriostatic at low concentrations but becomes bactericidal at higher concentrations. It is particularly effective in bacterial infections of the respiratory and gastrointestinal tracts.

Indications
Hemoflor Plus is indicated for the treatment of bacterial infections, including:

Respiratory Diseases:

Bovine Respiratory Disease (BRD) caused by M. haemolytica, P. multocida, and H. somni in cattle.
Porcine Respiratory Disease Complex (PRDC) in pigs.
Enteric Infections:

Infectious diarrhea or gastrointestinal diseases caused by susceptible bacterial pathogens.
Septicemia:

Bacterial infections causing systemic spread in livestock.
Other Conditions:

Secondary infections in weakened animals or following viral illnesses like IBR (Infectious Bovine Rhinotracheitis).
Dosage and Administration
Dosage Guidelines:
Cattle:

Dose: 20 mg/kg body weight.
Frequency: Administered via intramuscular (IM) or subcutaneous (SC) injection, typically as a single dose or repeated 48 hours later if necessary.
Pigs:

Dose: 15 mg/kg body weight.
Frequency: Administered via IM injection, usually as a single dose, with a follow-up 48 hours later if needed.
Horses (off-label use):

The use of Hemoflor Plus in horses is less common and may be off-label. Consult a veterinarian for specific recommendations.

Administration:

Inject via IM or SC, depending on the species and veterinary guidance.
Use a sterile syringe and needle to prevent contamination and secondary infections.
Treatment Duration:
Most bacterial infections require 48–72 hours of antibiotic activity. Repeat treatment as necessary, but always under veterinary supervision. hemoflor plus para gallos​
Pharmacokinetics
Absorption: Rapid absorption following IM or SC injection, ensuring fast therapeutic levels.
Distribution: Distributed to tissues with high concentrations in the lungs, gastrointestinal tract, and other infection-prone areas.
Elimination: Primarily excreted via urine and bile.
Benefits
Broad-Spectrum Activity: Effective against both Gram-positive and Gram-negative pathogens.
Rapid Action: Quickly reaches therapeutic levels, helping resolve infections promptly.
Convenience: Single or double dosing reduces handling stress for animals.
Low Resistance: Florfenicol is less prone to bacterial resistance compared to other antibiotics.
Precautions and Side Effects
Precautions:
Only use in animals with bacterial infections confirmed or strongly suspected to be susceptible to florfenicol.
Do not use in animals with known hypersensitivity to florfenicol.
Ensure appropriate withdrawal periods before slaughter or milk production.
Side Effects:
Localized swelling or pain at the injection site.
Mild gastrointestinal upset in some animals (e.g., diarrhea).
Rarely, allergic reactions or hypersensitivity.
Withdrawal Periods
Meat:
Cattle: 30–44 days (depending on the dose and route of administration).
Pigs: 14–21 days.
Milk: Florfenicol is generally not approved for use in lactating dairy cattle producing milk for human consumption. hemoflor plus para gallos​
Contraindications
Animals with severe kidney or liver dysfunction.
Pregnant or lactating animals unless advised by a veterinarian.
Animals intended for immediate slaughter or milk production (due to withdrawal periods).
Storage Instructions
Store at a controlled temperature (15°C–25°C or 59°F–77°F).
Protect from light and avoid freezing.
Use within the expiration period.

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Hemoflor Plus is a highly effective antibiotic for treating respiratory and systemic bacterial infections in livestock. Its broad-spectrum activity, ease of administration, and potency make it a valuable tool for veterinarians. However, its use should always follow a confirmed diagnosis and adhere to local regulatory guidelines to prevent antimicrobial resistance and ensure food safety.