IGF-1 LR3

IGF-1 LR3 is a synthetic analog of Insulin-like Growth Factor-1 (IGF-1), modified to have a longer half-life and increased potency compared to naturally occurring IGF-1. It is primarily researched for its anabolic, cell growth, and muscle regeneration effects in both medical and performance-enhancement contexts.

Chemical Profile
Full Name: Insulin-Like Growth Factor-1 Long Arg3
Molecular Formula: C990H1528N262O300S7
Molecular Weight: ~9200 Daltons
Half-life: ~20–30 hours (vs. ~20 minutes for native IGF-1)
Modifications:
Substitution of arginine (Arg) for glutamic acid (Glu) at position 3.
Extended amino acid chain length (83 amino acids vs. 70 in native IGF-1).
Mechanism of Action
IGF-1 LR3 binds to the IGF-1 receptor on cell surfaces, triggering intracellular signaling that promotes:

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Protein synthesis
Muscle cell proliferation
Glucose uptake
Fat metabolism (lipolysis)
Tissue regeneration and repair
Because of its modification, IGF-1 LR3:

Resists binding to IGF-binding proteins (IGFBPs), allowing more free, active hormone in circulation.
Stays active longer in the body, leading to prolonged anabolic effects.
Benefits and Uses
Veterinary & Research Uses:
Studied for muscle wasting, injury recovery, and growth promotion in animals (especially equine studies).
Investigated in wound healing, neurological repair, and bone regeneration.
Performance Enhancement (Off-label Use):
Muscle Growth: Increases lean body mass and muscle density.
Fat Loss: Promotes a leaner physique by improving insulin sensitivity and lipid metabolism.
Recovery: Accelerates healing from intense exercise or injury.
Endurance and Strength: May enhance muscular endurance and strength capacity.
Dosage Guidelines (Research Context)
Note: IGF-1 LR3 is not FDA-approved for human use outside of clinical trials or specific veterinary contexts.

Dosage Range: 20–100 mcg per day

Low Dose: 20–40 mcg/day
Moderate Dose: 50 mcg/day
High Dose: 80–100 mcg/day (used by advanced users)
Administration:

Subcutaneous (SQ) or intramuscular (IM) injection.
Often taken pre- or post-workout to maximize muscle uptake.
Cycle Duration: 4–6 weeks, followed by a break (due to receptor desensitization risks).

Potential Side Effects

Hypoglycemia (low blood sugar)
Joint pain and swelling
Intestinal growth (with excessive doses)
Organomegaly (organ enlargement with chronic overuse)
Injection site irritation
Carpal tunnel syndrome-like symptoms IGF-1 LR3Buy IGF-1 LR3
Storage & Handling
Powder Form: Store at 2–8°C (refrigerated) before reconstitution.
Reconstituted Solution: Stable for 30 days refrigerated.
Use bacteriostatic water for reconstitution.
Legal and Regulatory Status
Not approved for human use without prescription.
WADA Banned Substance: Prohibited in sports and horse racing.
Legal status varies by country; use is restricted or controlled in many jurisdictions.

Comparison: IGF-1 LR3 vs Native IGF-1

IGF-1 LR3 is a potent growth factor analog known for muscle-building, recovery, and anabolic properties, with long-lasting effects due to its resistance to binding proteins and extended half-life. While widely used in research and veterinary studies, it is associated with significant side effects and legal restrictions when misused in humans or animals.